> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/adding-a-single-variant-to-curate.md).
# Adding a single variant to Curate
To add one or several variants, use manual entry in **Curate**. Follow the instructions below.
Adding a single variant to Curate
## How to add a variant in **Curate**
{% stepper %}
{% step %}
In the navigation panel, select **Add new** (:plus-large:).
{% endstep %}
{% step %}
Select the **Variant** tab.
{% endstep %}
{% step %}
In the **Add new variant** dialog, select the variant type:
* **SNV**: Single nucleotide variant or indel variant
* **CNV:** Deletion or duplication
{% endstep %}
{% step %}
Enter variant details.
{% hint style="info" %}
Confirm the human genome reference (GRCh37 or GRCh38) in the [navigation panel](/emedgene/emedgene-curate-manual/curate_navigation_panel.md). The genome build must match the variant coordinates you enter in `Position`, `Position start`, and `Position end`.
{% endhint %}
***
**SNV variant details**
Enter variant details using genomic coordinates or an HGVS coding change. Versions earlier than v100.41 support genomic coordinates only.
* **Genomic position nomenclature**
| Field name | Expected input | Example |
| ------------ | ------------------------------------------------ | -------- |
| `Chromosome` | `1` - `22`, `X`, `Y`, `M` | `X` |
| `Position` | Integer | `123000` |
| `REF` | `A`, `T`, `G`, `C`, or a string of these letters | `G` |
| `ALT` | `A`, `T`, `G`, `C`, or a string of these letters | `GACT` |
* **Coding change nomenclature (v100.41+)**
| Field name | Expected input | Example |
| ------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------- |
| `Gene` | Search by gene symbol, NCBI ID, or HGNC ID | `SMN1` |
| `Transcript` |
Select from the options. If a preferred transcript is set on the gene’s Curate page, it is selected by default and marked with a star.
| `NM_000344.4` |
| `c.dot` | Coding change |
SNV: c.403G>T Small insertion: c. 4713\_4714insTA Small deletion: c.65\_66del
|
**CNV variant details**
| Field name | Expected input | Example |
| ---------------- | ------------------------------------------------ | -------- |
| `Chromosome` | `1` - `22`, `X`, `Y`, `M` | `14` |
| `Position start` | Integer | `123000` |
| `Position end` | Integer. Must be greater than `Position start`. | `124000` |
| `REF` | `A`, `T`, `G`, `C`, or a string of these letters | `G` |
| `Type` | `DEL`, `DUP` | `DEL` |
***
{% endstep %}
{% step %}
Select **Add**.
{% endstep %}
{% endstepper %}
{% hint style="info" %}
If you are adding a CNV with **70% or higher annotation overlap** with an existing CNV of the same type (DEL/DUP), an **Overlap variant** card appears listing matching variants. Choose **Add anyway** to create the variant, **Cancel** to edit your entry, or open an existing variant from the table. If the variant is **identical**, the message **This variant already exists in your Curate** is shown and **Add anyway** is disabled.
{% endhint %}
**Result:**
* Variant is added to **Curate**.
* The [**Curate Variant page**](/emedgene/emedgene-curate-manual/curate_variants/curate_variant_page.md) opens, where you can assign pathogenicity, add curated interpretation, select a disease, classify the variant using ACMG criteria, and perform additional actions as needed.
## Alternative ways to add variants to **Curate**
Unsure if manual variant entry in **Curate** is the right option?
* Upload a CSV file to efficiently handle a large set of variants. :up-right-from-square: [Learn more](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/adding-or-updating-multiple-variants-in-curate.md)
* Export a variant directly from a case in **Analyze**. :up-right-from-square: [Learn more](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/exporting-a-variant-from-analyze.md)
---
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