> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/emedgene/emedgene-curate-manual/curate_genes_2_28/curate_gene_page/gene-metrics-card.md). # Gene Metrics card ## Card contents The **Gene Metrics card** displays gene metrics from ExAC, gnomAD and ClinGen that assess the potential pathogenic impact of gene alterations: * **RVIS** — Residual variation intolerance score * **p(LoF intolerant)** — Probability of loss of function intolerance * **p(REC)** — Probability of being intolerant to homozygous, but not heterozygous LoF variants * **O/E score** — Ratio of the observed/expected number of LoF variants * **HI** — Haploinsufficiency * **TS** — Triplosensitivity * **Z missense** — Intolerance to missense variants based on the deviation of observed missense variants versus the expected number
Gene Metrics card.
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