> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/emedgene/emedgene-analyze-manual/variant_page/clinical_significance_section.md).

# Clinical significance tab

The **Clinical Significance tab** provides essential variant-level and gene-level details to help you evaluate a variant’s potential pathogenicity. It combines AI-driven insights with curated public data for informed interpretation.

## Information is organized into the following cards:

* [**Variant info**](/emedgene/emedgene-analyze-manual/variant_page/clinical_significance_section/variant-info.md): Displays key details such as HGVS nomenclature, predicted effect, variant type, zygosity, phasing (v100.40.0+), and links to external databases.
* [**In silico predictions**](/emedgene/emedgene-analyze-manual/variant_page/clinical_significance_section/in-silico-predictions.md): Shows individual tool results and algorithmic predictions for missense, conservation, and splicing effects.
* [**Gene metrics**](/emedgene/emedgene-analyze-manual/variant_page/clinical_significance_section/gene-metrics.md): Summarizes gene’s level of intolerance to different types of variation.
* [**Clinical significance**](/emedgene/emedgene-analyze-manual/variant_page/clinical_significance_section/clinical-significance.md): Highlights previous pathogenicity classifications from your lab and public sources.
* [**Gene-related diseases**](/emedgene/emedgene-analyze-manual/variant_page/clinical_significance_section/gene-related-diseases.md): Lists known gene–disease associations with inheritance patterns and source links.

<figure><img src="https://1131024994-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGCW0DnLlE7QjoZPNmKIi%2Fuploads%2Fgit-blob-8a2da5e455259e33fcc76dd9bcbe5993cff3152c%2Fclinical%20significance%20tab.gif?alt=media" alt=""><figcaption><p>Clinical significance tab on v100.39.0</p></figcaption></figure>


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