> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/emedgene/emedgene-analyze-manual/tertiary-analysis-pipeline/annotation_updates.md).

# Emedgene annotations and update frequency

Every case is annotated with the attached table of resources, including proprietary Illumina prediction scores PrimateAI-3D and SpliceAI. All annotations are versioned, and versions recorded in a Versions tab, and saved per case. Key variant significance and knowledge graph databases are updated monthly, so that the most up-to-date information is available during analysis.

{% file src="/files/yHjm9r4U32R7QKCmdWze" %}


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