> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/dragen/dragen-v4.6/product-guides/dragen-v4.6/germline/illumina-trupath/cnv_accuracy.md).
# TruPath Copy Number Variation
Generated on **2026-06-10**
## Copy Number Variation
The DRAGEN Copy Number Variant (CNV) Pipeline can call CNV events using next-generation sequencing (NGS) data. This pipeline supports multiple applications in a single interface via the DRAGEN Host Software, including processing of whole-genome sequencing (WGS) data and whole-exome sequencing (WES) data. For more information, refer to the [DRAGEN user guide for germline CNV calling](/dragen/dragen-v4.6/product-guides/dragen-v4.6/dragen-dna-pipeline/cnv-overview/cnv-germline.md).
**DRAGEN**: DRAGEN 4.5.4 | **Truthset**: HG002 NIST CNV v0.6 | **Reference**: GRCh38
TruPath CNV summary (click to expand)
| Subtype | Recall | Precision | F1-score |
| --------- | ------ | --------- | -------- |
| 1kb-10kb | 0.953 | 0.988 | 0.970 |
| 10kb-50kb | 0.929 | 0.968 | 0.948 |
| >50kb | 1.000 | 1.000 | 1.000 |
---
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