> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/dragen-clinical-research-apps/readme/dragen-solid-wgs-tn-pipeline/setup/advanced/custom_config.md).

# Custom Config Support

This feature allows users to customize a specific set of DRAGEN command-line options to override the default values pre-defined in the pipeline.

## Cloud Setup

On the BioInsight Platform Core user interface (UI) to the software, you can specify the **Custom Parameters Config File** and **Custom Resources Directory** directly. Supported customizable options are described below.

## Examples

### `solid_custom_param.config` Content

```bash
## custom parameters
somatic_vc_output_evidence_bam = false
germline_qc_detect_contamination = true
germline_aligner_clip_pe_overhang = 0

## custom reference files
somatic_sv_systematic_noise = '/snv/WGS_hg38_v1.0_systematic_noise.snv.bed.gz'
somatic_sv_systematic_noise = '/sv/WGS_FF_solid_hg38_v1.0_systematic_noise.sv.bedpe.gz'
somatic_vc_somatic_hotspots = '/snv/somatic_hotspots_GRCh38.vcf.gz'
```

### `custom_resources_Heme_dir` Folder Structure on cloud

```
custom_resources_Solid/
├── snv
│   ├── WGS_Solid_hg38_v1.0_systematic_noise.snv.bed.gz
│   └── somatic_hotspots_GRCh38.vcf.gz
└── sv
    └── WGS_Solid_FF_solid_hg38_v1.0_systematic_noise.sv.bedpe.gz
```

> **ℹ️ Note:**\
> Custom resource files and the custom configuration file must be uploaded to the same Platform Core project where the run is created.\
> You can use the `icav2` client or other supported methods.\
> See [Data Transfer Options with Platform Core](https://help.ica.illumina.com/tutorials/datatransfer) for details.

### Cloud Input Files UI Example

![ICA Setup Screenshot](https://2414276024-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FjdZwGT2DsEhB6cr9Abe8%2Fuploads%2Fgit-blob-9b4fa1663c6eb80582787f4d7dc254caf95d47d0%2Fica-setup-screenshot.png?alt=media)


---

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