> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/dragen-clinical-research-apps/readme/common/advanced.md).

# Advanced Topics

The pipeline may be downloaded and installed on a local DRAGEN server. A download utility may be obtained from the Illumina download site, and the download utility will manage all the dependencies. Once the required installers are downloaded, the software may be installed by running the installers.

## Using NFS for data streaming

With the NovaSeq X 25B flow cells, the amount of data is on the order of terabytes, which may take a few hours or more to copy to the /staging folder on the local DRAGEN server. Using NFS storage directly for input and output is recommended in this case.

## Variant Interpretation

ICI supports variant interpretation with advance visualization capabilities. It is available in the cloud or on a local DRAGEN server.


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