> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/correlation-engine/about/about.md). # About Correlation Engine **Illumina Correlation Engine** is a cloud-based software platform that provides tools and curated content for exploratory, preclinical, and early translational research in drug discovery and biotechnology. It functions as a multidimensional integration platform, enabling researchers to search and statistically correlate global collections of heterogeneous, large-scale experimental data across diverse platforms, organisms, and therapeutic areas. ## What Is Correlation Engine? Correlation Engine aggregates and indexes tens of thousands of public genomic studies alongside privately imported data, then allows users to query this entire corpus simultaneously using genes, concepts, biosets, or sequence regions. Rather than searching scientific literature, Correlation Engine works directly from experimental data—meaning you can discover associations that may not yet appear in published papers. At its core, Correlation Engine uses proprietary rank-based statistical algorithms to score and rank correlations across the following categories of data: * **Diseases and phenotypes** — via Disease Atlas * **Tissues and cell types** — via Body Atlas (including single-cell data) * **Compounds and treatments** — via Pharmaco Atlas * **Genetic perturbations** — via Knockdown Atlas * **Pathways and protein families** — via Biogroups (Pathway Enrichment) * **Cross-study consensus signatures** — via Meta-Analysis * **Clinical and literature context** — via Literature and Clinical Trials apps ## Integration with Illumina Connected Multiomics Correlation Engine is deeply integrated with [Illumina Connected Multiomics (ICM)](https://help.connected.illumina.com/icm). ICM is the platform used to organize, manage, and perform statistical analysis of multiomics data. Once a differential expression or other statistical analysis is completed in ICM, the resulting data can be exported as a **bioset** and imported into Correlation Engine for biological interpretation. {% hint style="info" %} Access to Correlation Engine requires the **Illumina Connected Multiomics Professional** subscription tier. The Basic tier does not include CE integration. For plans and pricing, see the [ICM About page](https://help.connected.illumina.com/icm/about/readme.md). {% endhint %} ## Subscription Tiers | Tier | CE Access | | ------------------------------------- | ----------------------------------------------------------------------- | | **BioInsight Platform Basic** | Not included | | **Connected Multiomics Professional** | Full access — import, query all apps, export results | | **Correlation Engine Enterprise** | Full access plus domain libraries, bulk import API, group-level sharing | ## Public Data Content The Correlation Engine public library is one of the largest curated collections of genomic data available: | Content | Count (as of v2.9.0) | | --------------------------------- | -------------------- | | Public studies | 27,566 | | Public biosets | 202,676 | | Single-cell biosets in Body Atlas | 3,287 | Data sources include [Gene Expression Omnibus (GEO)](https://www.ncbi.nlm.nih.gov/geo/), [Array Express](https://www.ebi.ac.uk/arrayexpress/), [The Cancer Genome Atlas (TCGA)](https://cancergenome.nih.gov/), [ClinicalTrials.gov](https://clinicaltrials.gov/), and manually curated studies from published literature. ## Supported Organisms Correlation Engine supports correlation of data across multiple organisms, with cross-species comparisons enabled through ortholog mappings from Mouse Genome Informatics, HomoloGene, and Ensembl. Commonly used species include *Homo sapiens*, *Mus musculus*, *Rattus norvegicus*, *Danio rerio*, *Drosophila melanogaster*, and *Caenorhabditis elegans*. ## Supported Data Types Correlation Engine accepts the following data types for import: | Abbreviation | Data Type | | ------------ | ------------------------------ | | RE | RNA Expression | | MI | miRNA Expression | | ME | DNA Methylation | | PD | Protein-DNA Binding (ChIP-seq) | | CN | DNA Copy Number | | SM | Somatic Mutation | | GT | SNP / GWAS | | AT | ATAC-seq | | PE | Protein Expression | | MU | Mutations / Phenotypic | | SC | Single-cell RNA-seq | ## Security Correlation Engine is hosted on Amazon Web Services (AWS) and is covered by Illumina's ISO 27001–certified information security program. Key security features include full audit trails, TLS 1.2 encryption in transit, AES-256 encryption at rest, and automated data integrity checks. See the [Illumina Data Security and Privacy Statement](https://www.illumina.com/content/dam/illumina/gcs/assembled-assets/marketing-literature/data-security-privacy-statement-m-gl-00709/data-security-privacy-statement-m-gl-00709.pdf) for full details. --- # Agent Instructions This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com. ## Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation by asking a question. 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