> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/connected-insights/configure/configuration/c-test-definition-setup.md).

# Test Definitions

Test Definitions allow you to specify default parameters that apply to cases when they are ingested. Make sure you have test components created, then create a test definition as follows.

1. On the top toolbar, select **Configuration**.
2. Select the **Test Definitions** tab.
3. Select **New**.
4. In the right-hand pane, enter a test name in the Test Name field.
5. Choose a human reference genome.
6. \[Optional] Select one or more custom annotations (must be compatible for the selected human reference genome).
7. \[Optional] Choose a virtual panel option to restrict variant display to a specific set of genes.
8. \[Optional] Configure one or more disease configurations for this test. Workgroup-level [disease configurations](/connected-insights/configure/configuration/c-disease-configuration.md) are available by default and can be overridden to create test-specific configurations. Test specific configurations are applied to all cases processed using the test definition.
   * Select **Edit** to view and edit disease configuration.
   * Select **New** to add disease configuration.
   * Select **Delete** or **Delete All** to delete disease configuration(s).
   * Select **Reset to Default** to restore disease configurations to the workgroup-level [disease configurations](/connected-insights/configure/configuration/c-disease-configuration.md).
9. Choose a [variant flag group](/connected-insights/configure/configuration/c-variant-flag-groups.md).
10. Choose one or more variant filters. These filters display in the [Variants Tab](/connected-insights/interpret-and-report/inter-variant-grid.md) as locked filters.
11. Choose a [report template](/connected-insights/configure/configuration/reports-report-templates.md).
12. \[Optional] Select the **Turn on Report Automation** toggle to enable or disable the automated addition of assertions to reports using this test definition. For more information, refer to [Report Automation](/connected-insights/configure/configuration/c-automation.md).
13. \[Optional] Enter version comments as applicable.
14. \[Optional] Enter a test methodology to be included on the PDF report.
15. Select **Save**. The new test definition appears on the left-hand accordion menu. Select a test definition to preview and access the following actions:
    * Select **Edit** to edit a test definition.
    * Select **Copy As New** to copy the definition as a template for a new test definition.
    * Select **Archive** to hide the test definition from the PDF report.

## Default Tests

Connected Insights provides the following default tests, marked **Provided by Illumina**, to assist in preliminary test implementation. Default tests cannot be updated; select **Copy As New** to copy one into your workgroup and adjust it. See [Illumina-Provided Default Resources](/connected-insights/configure/configuration.md#illumina-provided-default-resources).

| Test                                                              | Genome Build | Default Filters                                        | Virtual Panel (see note 1) | Test-Specific Disease Groups (see note 2) |
| ----------------------------------------------------------------- | ------------ | ------------------------------------------------------ | -------------------------- | ----------------------------------------- |
| TruSight Oncology 500 Solid Tumor                                 | GRCh37       | All Demo, SNV Demo, SV Demo, CNV Demo, RNA Splice Demo | —                          | —                                         |
| TruSight Oncology 500 ctDNA                                       | GRCh37       | All Demo, SNV Demo, SV Demo, CNV Demo                  | —                          | —                                         |
| Pillar oncoReveal Multi-Cancer DNA and RNA Fusion - Virtual Panel | GRCh37       | All Demo, SNV Demo, SV Demo, CNV Demo, RNA Splice Demo | Disease key genes          | Yes                                       |
| Pillar oncoReveal Multi-Cancer DNA and RNA Fusion                 | GRCh37       | All Demo, SNV Demo, SV Demo, CNV Demo, RNA Splice Demo | —                          | Yes                                       |
| Pillar oncoReveal Myeloid Panel                                   | GRCh37       | SNV Demo                                               | —                          | Yes                                       |
| Pillar oncoReveal Core LBx Panel                                  | GRCh37       | All Demo, SNV Demo, CNV Demo                           | —                          | Yes                                       |
| Whole Genome Solid Tumor                                          | GRCh38       | All Demo, SNV Demo, CNV Demo, SV Demo                  | —                          | —                                         |
| Whole Genome Solid Tumor-Normal                                   | GRCh38       | All Demo, SNV Demo, CNV Demo, SV Demo                  | —                          | —                                         |
| Whole Genome Heme                                                 | GRCh38       | AML Demo, SNV Demo, CNV Demo, SV Demo                  | —                          | —                                         |
| Whole Exome Solid Tumor                                           | GRCh38       | All Demo, SNV Demo, CNV Demo, SV Demo                  | —                          | —                                         |
| Whole Exome Solid Tumor-Normal                                    | GRCh38       | All Demo, SNV Demo, CNV Demo, SV Demo                  | —                          | —                                         |
| Whole Exome cfDNA Enrichment                                      | GRCh38       | All Demo, SNV Demo, CNV Demo                           | —                          | —                                         |
| Whole Exome FFPE Tumor-Normal Enrichment                          | GRCh38       | All Demo, SNV Demo, CNV Demo, SV Demo                  | —                          | —                                         |
| Whole Transcriptome Sequencing                                    | GRCh38       | All Demo, SV Demo, RNA Splice Demo                     | —                          | —                                         |
| MRD Whole Genome Sequencing                                       | GRCh38       | All Demo                                               | —                          | —                                         |
| Archer FUSIONPlex Pan Solid Tumor v2 Panel                        | GRCh37       | All Demo, SNV Demo, SV Demo, RNA Splice Demo           | —                          | Yes                                       |
| Archer FUSIONPlex Pan-Heme v2 Panel                               | GRCh37       | AML Demo, SNV Demo, SV Demo, RNA Splice Demo           | —                          | Yes                                       |
| Archer VARIANTPlex Pan Solid Tumor v2 Panel                       | GRCh37       | All Demo, SNV Demo, CNV Demo                           | —                          | Yes                                       |
| Archer VARIANTPlex Myeloid v2 Panel                               | GRCh37       | SNV Demo, CNV Demo                                     | —                          | Yes                                       |
| TruSight Tumor 170 Virtual Panel with WGS                         | GRCh38       | All Demo, SNV Demo, CNV Demo, SV Demo                  | 170-gene list              | —                                         |

The default filters are described in [Variant Filters](/connected-insights/configure/configuration/c-variant-filters.md#default-filters).

**Notes**

1. **Virtual panel design.** A virtual panel restricts the variants that are ingested to a set of genes. Structural variants that do not overlap one of those genes are not ingested.

   * **Disease key genes** — The genes are the key genes of the disease group that applies to the case, taken from the test-specific disease groups of the test.
   * **170-gene list** — The genes are a fixed list of 170 genes from the TruSight Tumor 170 gene set.

   Tests marked — have no virtual panel.
2. **Test-specific disease group design.** A test-specific disease group applies to cases processed with that test, and replaces the [workgroup-level disease configuration](/connected-insights/configure/configuration/c-disease-configuration.md) for them. Each test with test-specific disease groups follows the same design:
   * The key genes of a disease group are the workgroup-level key genes for that group, limited to the genes the assay covers. Genes that the assay does not cover are removed, and no genes are added from other sources.
   * Each group keeps the name, display order, and associated disease terms of the workgroup-level group.
   * Solid tumor assays include the solid tumor disease groups (Bone, Breast, CNS, Colorectal, Lung, Melanoma, Ovarian, Prostate, Thyroid, and Uterine And Cervical). Heme assays include the AML disease group only.
   * Every test also includes a **Default all Unspecified Diseases** group. Its key genes are all the genes the assay covers, and it applies to diseases that no other group matches.
   * TMB, MSI, and HRD thresholds are not set in the test-specific disease groups. Cases use the thresholds of the workgroup-level disease configuration.


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