> For the complete documentation index, see [llms.txt](https://help.bioinsight.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.bioinsight.illumina.com/annotation/introduction/whats-new.md).

# What's new

<table data-view="cards"><thead><tr><th></th><th></th><th></th><th data-hidden data-card-cover data-type="image">Cover image</th><th data-hidden data-card-target data-type="content-ref"></th></tr></thead><tbody><tr><td><strong>Introducing SpliceAI2: The Next Generation of Splicing and Transcript Isoform Prediction</strong></td><td>Blog post introducing SpliceAI2</td><td><em>October 2026</em></td><td><a href="https://3508920906-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F0ADJyhzPlTHw5HimbPLQ%2Fuploads%2Fgit-blob-c55386c9f64f3693be6cfbd518e64c9de6e01e57%2F6951%20Illumina%20US%20-%20SpliceAI2_Hero%20Image_Upscale.jpg?alt=media">6951 Illumina US - SpliceAI2_Hero Image_Upscale.jpg</a></td><td><a href="https://www.illumina.com/science/genomics-research/articles/introducing-spliceai2--the-next-generation-of-splicing-and-trans.html">https://www.illumina.com/science/genomics-research/articles/introducing-spliceai2--the-next-generation-of-splicing-and-trans.html</a></td></tr><tr><td><strong>AI tools fast-track non-coding variant interpretation</strong></td><td>Nature Portfolio article on deep-learning based AI tools</td><td><em>October 2026</em></td><td><a href="https://3508920906-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2F0ADJyhzPlTHw5HimbPLQ%2Fuploads%2Fgit-blob-a984e2353fc3107442b3610edb72fb367b0006ff%2Fd42473-026-00188-0_53679204.webp?alt=media">d42473-026-00188-0_53679204.webp</a></td><td><a href="https://www.nature.com/articles/d42473-026-00188-0">https://www.nature.com/articles/d42473-026-00188-0</a></td></tr><tr><td><strong>Illumina leads the industry in genomic AI</strong></td><td>The company has proven its ability to decode the unknown regions of the genome</td><td><em>November 2025</em></td><td><a href="https://assets.illumina.com/content/dam/illumina-marketing/images/company/featured-articles-v2/KyleFarhAI.jpg">https://assets.illumina.com/content/dam/illumina-marketing/images/company/featured-articles-v2/KyleFarhAI.jpg</a></td><td><a href="https://www.illumina.com/company/news-center/feature-articles/leadership-perspectives--illumina-leads-the-industry-in-genomic-.html">https://www.illumina.com/company/news-center/feature-articles/leadership-perspectives--illumina-leads-the-industry-in-genomic-.html</a></td></tr><tr><td><strong>How Do You Train Genomics AI?</strong></td><td>On Natural Selection Itself, Says VP of Illumina's AI Lab, Kyle Farh</td><td><em>April 2024</em></td><td><a href="https://assets.illumina.com/content/dam/illumina-marketing/images/genomics-podcast/podcast-holder.jpg">https://assets.illumina.com/content/dam/illumina-marketing/images/genomics-podcast/podcast-holder.jpg</a></td><td><a href="https://www.illumina.com/science/genomics-podcast/how-do-you-train-genomics-ai-on-natural-selection-itself-says-vp-of-illuminas-ai-lab-kyle-farh.html">https://www.illumina.com/science/genomics-podcast/how-do-you-train-genomics-ai-on-natural-selection-itself-says-vp-of-illuminas-ai-lab-kyle-farh.html</a></td></tr><tr><td><strong>Leverage genomic AI to deliver a more accurate and comprehensive genome</strong></td><td>Webinar from Dr. Min Li</td><td><em>April 2024</em></td><td><a href="https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==">https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==</a></td><td><a href="https://www.illumina.com/events/webinar/2024/leverage-genomic-ai-deliver-more-accurate-comprehensive-genome.html">https://www.illumina.com/events/webinar/2024/leverage-genomic-ai-deliver-more-accurate-comprehensive-genome.html</a></td></tr><tr><td><strong>Illumina AI: PrimateAI-3D and SpliceAI for precision medicine and drug discovery</strong></td><td>Webinar from Dr. Kyle Farh</td><td><em>April 2024</em></td><td><a href="https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==">https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==</a></td><td><a href="https://www.illumina.com/events/webinar/2024/illumina-artificial-intelligence-primate-ai-3d-splice-ai-precision-medicine-drug-discovery.html">https://www.illumina.com/events/webinar/2024/illumina-artificial-intelligence-primate-ai-3d-splice-ai-precision-medicine-drug-discovery.html</a></td></tr><tr><td><strong>Unveiling Illumina Connected Annotations: A breakthrough in genomic annotation</strong></td><td>Illumina announces a new launch for their best-in-class variant annotation software solution</td><td><em>April 2024</em></td><td><a href="https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==">https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==</a></td><td><a href="https://www.illumina.com/science/genomics-research/articles/Connected-Annotations-blog.html">https://www.illumina.com/science/genomics-research/articles/Connected-Annotations-blog.html</a></td></tr><tr><td><strong>What our primate relatives can teach us about our own genomes</strong></td><td>A new algorithm trained by natural selection can pinpoint disease-causing variants in humans</td><td><em>June 2023</em></td><td><a href="https://assets.illumina.com/content/dam/illumina-marketing/images/company/featured-articles-v2/PrimateAI-3D_1.png">https://assets.illumina.com/content/dam/illumina-marketing/images/company/featured-articles-v2/PrimateAI-3D_1.png</a></td><td><a href="https://www.illumina.com/company/news-center/feature-articles/PrimateAI-3D.html">https://www.illumina.com/company/news-center/feature-articles/PrimateAI-3D.html</a></td></tr><tr><td><strong>Improving genetic risk prediction and drug target discovery using primate DNA and advanced artificial intelligence</strong></td><td>Blog post on PrimateAI-3D</td><td><em>June 2023</em></td><td><a href="https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9Nb25rZXlzLmpwZyIsImVkaXRzIjp7ImpwZWciOnsicXVhbGl0eSI6MTAwLCJwcm9ncmVzc2l2ZSI6ZmFsc2UsInRyZWxsaXNRdWFudGlzYXRpb24iOnRydWUsIm92ZXJzaG9vdERlcmluZ2luZyI6dHJ1ZSwib3B0aW1pemVTY2FucyI6dHJ1ZX0sInJlc2l6ZSI6eyJ3aWR0aCI6NzIwLCJoZWlnaHQiOjUyOCwiZml0IjoiY292ZXIifSwic2hhcnBlbiI6dHJ1ZX19">https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9Nb25rZXlzLmpwZyIsImVkaXRzIjp7ImpwZWciOnsicXVhbGl0eSI6MTAwLCJwcm9ncmVzc2l2ZSI6ZmFsc2UsInRyZWxsaXNRdWFudGlzYXRpb24iOnRydWUsIm92ZXJzaG9vdERlcmluZ2luZyI6dHJ1ZSwib3B0aW1pemVTY2FucyI6dHJ1ZX0sInJlc2l6ZSI6eyJ3aWR0aCI6NzIwLCJoZWlnaHQiOjUyOCwiZml0IjoiY292ZXIifSwic2hhcnBlbiI6dHJ1ZX19</a></td><td><a href="https://www.illumina.com/science/genomics-research/articles/primateai-3d.html">https://www.illumina.com/science/genomics-research/articles/primateai-3d.html</a></td></tr><tr><td><strong>Predicting splicing from primary sequence with deep learning</strong></td><td>Blog post on SpliceAI</td><td><em>November 2020</em></td><td><a href="https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==">https://assets.developer.illumina.com/eyJidWNrZXQiOiJhc3NldHMuaWxsdW1pbmEuY29tIiwia2V5IjoiaW1hZ2VzL2NvdmVycy9kcmFnZW4tcGVyc3BlY3RpdmUtY2hpcC13ZWItZ3JhcGhpY18yMDIyLTA1LTI0LTIxMDUyM19iYmN5LmpwZWciLCJlZGl0cyI6eyJqcGVnIjp7InF1YWxpdHkiOjEwMCwicHJvZ3Jlc3NpdmUiOmZhbHNlLCJ0cmVsbGlzUXVhbnRpc2F0aW9uIjp0cnVlLCJvdmVyc2hvb3REZXJpbmdpbmciOnRydWUsIm9wdGltaXplU2NhbnMiOnRydWV9LCJyZXNpemUiOnsid2lkdGgiOjkxMiwiZml0IjoiaW5zaWRlIn0sInNoYXJwZW4iOnRydWV9fQ==</a></td><td><a href="https://www.illumina.com/science/genomics-research/articles/predict-splicing-primary-sequence-deep-learning.html">https://www.illumina.com/science/genomics-research/articles/predict-splicing-primary-sequence-deep-learning.html</a></td></tr></tbody></table>


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